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Olsen EA. Current and novel methods for assessing efficacy of hair growth promoters in pattern hair loss. J Am Acad Dermatol. 2003;48:253-262. Abstract
Torres F, Tosti A. Female pattern alopecia and telogen effluvium: figuring out diffuse alopecia. Semin Cutan Med Surg. 2015;34:67-71. Abstract
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Torres F, Tosti A. Trichoscopy: an update. G Ital Dermatol Venereol. 2014;149:83-91. Abstract
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Tosti A, Piraccini BM, Iorizzo M, Misciali C. Frontal fibrosing alopecia in postmenopausal women. J Am Acad Dermatol. 2005;52:55-60. Abstract
Cotsarelis G, Millar SE. Towards a molecular understanding of hair loss and its treatment. Trends Mol Med. 2001;7:293-301. Abstract
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Sawaya ME, Shalita AR. Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. J Cutan Med Surg. 1998;3:9-15. Abstract
Calvo RM, Asunción M, Sancho J, San Millán JL, Escobar-Morreale HF. The role of the CAG repeat polymorphism in the androgen receptor gene and of skewed X-chromosome inactivation, in the pathogenesis of hirsutism. J Clin Endocrinol Metab. 2000;85:1735-1740. Abstract
Yip L, Zaloumis S, Irwin D, Severi G, Hopper J, Giles G, et al. Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss. Br J Dermatol. 2009;161:289-294. Abstract
Redler S, Tazi-Ahnini R, Drichel D, Birch MP, Brockschmidt FF, Dobson K, et al. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Exp Dermatol. 2012;21:390-393. Abstract
Price VH. Androgenetic alopecia in adolescents. Cutis. 2003;71:115-121. Abstract
Sawaya ME, Price VH. Different levels of 5α-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol.1997;109:296-300. Abstract
Schmitt JV, Ribeiro CF, Souza FH, Siqueira EB, Bebber FR. Hair loss perception and symptoms of depression in female outpatients attending a general dermatology clinic. An Bras Dermatol. 2012;87:412-417. Abstract
Cash TF. The psychosocial consequences of androgenetic alopecia: a review of the research literature. Br J Dermatol. 1999;141:398-405. Abstract
Camacho FM, García-Hernández M. Psychological features of androgenetic alopecia. J Eur Acad Dermatol Venereol. 2002;16:476-480. Abstract
Van der Donk EM, Hunfeld JA, Passchier J, Knegt-Junk KJ, Nieboer C.l. Quality of life and maladjustment associated with hair loss in women with alopecia androgenetica. Soc Scie Med. 1994;38:159-163.
Price VH, Roberts JL, Hordinsky M, et al. Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. J Am Acad Dermatol. 2000;43:768-776. Abstract
Rogaine® (minoxidil). Johnson & Johnson. New Brunswick, NJ. November 2015.
Blumeyer A, Tosti A, Messenger A, Reygagne P, Del Marmol V, Spuls PI, et al. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. J Dtsch Dermatol Ges. 2011;9:S1-S57.
Blume-Peytavi U, Hillmann K, Dietz E, Canfield D, Garcia Bartels N. A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. J Am Acad Dermatol. 2011;65:1126-1134. Abstract
Propecia® (finasteride) Merck. Whitehouse Station, NJ. September 2013.
Iorizzo M, Vincenzi C, Voudouris S, et al. Finasteride treatment of female pattern hair loss. Arch Dermatol. 2006;142:298-302. Abstract
Kohler C, Tschumi K, Bodmer C, Schneiter M, Birkhaeuser M. Effect of finasteride 5 mg (Proscar) on acne and alopecia in female patients with normal serum levels of free testosterone. Gynecol Endocrinol. 2007;23:142-145. Abstract
Trueb RM. Finasteride treatment of patterned hair loss in normoandrogenic postmenopausal women. Dermatology. 2004;209:202-207. Abstract
Avodart ® (dutasteride) GlaxoSmithKline. Research Triangle Park, NC. September 2014.
Eun HC, Kwon OS, Yeon JH, et al. Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study. J Am Acad Dermatol. 2010;63:252-258. Abstract
Stough D. Dutasteride improves male pattern hair loss in a randomized study in identical twins. J Cosmet Dermatol. 2007;6:9-13. Abstract
Olsen EA, Hordinsky M, Whiting D, et al; Dutasteride Alopecia Research Team. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. J Am Acad Dermatol. 2006;55:1014-1023. Abstract
Moftah N, Abd-Elaziz G, Ahmed N, Hamed Y, Ghannam B, Ibrahim M. Mesotherapy using dutasteride-containing preparation in treatment of female pattern hair loss: photographic, morphometric and ultrustructural evaluation. J Eur Acad Dermatol Venereol. 2013;27:686-693. Abstract
Leyden J, Dunlap F, Miller B, et al. Finasteride in the treatment of men with frontal male pattern hair loss. J Am Acad Dermatol. 1999;40:930-937. Abstract
Boychenko O, Bernstein RM, Schweiger ES. Finasteride in the treatment of female pattern (androgenic) alopecia: a case report and review of the literature. Cutis. 2012;90:73-76. Abstract
Adamopoulos DA, Karamertzanis M, Nicopoulou S, Gregoriou A. Beneficial effect of spironolactone on androgenic alopecia. Clin Endocrinol (Oxf). 1997;47:759-760. Abstract
Sinclair R, Wewerinke M, Jolley D. Treatment of female pattern hair loss with oral antiandrogens. Br J Dermatol. 2005;152:466-473. Abstract
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Park JH, Moh US, Lee SY, You SH. Micropigmentation: camouflaging scalp alopecia and scars in Korean patients. Aesthetic Plast Surg. 2014;38:199-204. Abstract
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Jacobs JP, Szpunar CA, Warner ML. Use of topical minoxidil therapy for androgenetic alopecia in women. Int J Dermatol. 1993;32:758-762. Abstract
Lucky AW, Piacquadio DJ, Ditre CM, et al. A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. J Am Acad Dermatol. 2004;50:541-553. Abstract
van Zuuren EJ, Fedorowicz Z, Carter B, Andriolo RB, Schoones J. Interventions for female pattern hair loss. Cochrane Database Syst Rev. 2012;5:CD007628.
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Rathnayake D, Sinclair R. Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss. Dermatol Clin. 2010;28:611-618. Abstract
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Faculty

Antonella Tosti, MD

Activity Chair and Professor, Department of Dermatology & Cutaneous Surgery, University of Miami, Miami, Florida

Disclosures

Disclosure: Antonella Tosti, MD has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Aclaris Therapeutics, Inc., DS Laboratories, Incyte Corporation, Kythera Biopharmaceuticals, Polichem, Procter & Gamble

Dr Tosti does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

Dr Tosti does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Lakshi M. Aldrege, MSN, ANP-BC

Nurse Practitioner, Dermatology Service, VA Portland Health Care System, Portland, Oregon

Disclosures

Disclosure: Lakshi M. Aldrege, NP has disclosed the following relevant financial relationships:
Served as a speaker or a member of a speakers bureau for: AbbVie Inc., Celgene Corporation, Eli Lilly and Company, Novartis Pharmaceuticals Corporation, Pfizer, Inc.

Ms Aldrege does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

Dr Aldrege does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Amy J. McMichael, MD

Professor, Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, North Carolina

Disclosures

Disclosure: Amy J. McMichael, MD has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Allergan, Covance Inc., eResearch Technology, Inc., Galderma Laboratories, LP, Guthey Renker, Incyte Corporation, Johnson & Johnson, KeraNetics LLC, Merck & Co., Inc., Merz Inc., Proctor & Gamble, Samumed, LLC
Received grants for clinical research from: Allergan, Proctor & Gamble, Samumed LLC
Other: Royalties from: Informa Healthcare, UpToDate

Dr McMichael does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

Dr McMichael does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Editor

Shari J. Dermer, PhD

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Shari J. Dermer, PhD has disclosed no relevant financial relationships.

CE Reviewer/Nurse Planner

Amy Bernard, MS, BSN, RN-BC

Lead Nurse Planner, Medscape, LLC

Disclosures

Disclosure: Amy Bernard, MS, BSN, RN-BC, has disclosed no relevant financial relationships.

Patrick Dwyer

Director, CME, Center for Continuing and Outreach Education at Rutgers Biomedical and Health Sciences

Disclosures

Disclosure: Patrick Dwyer has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed for relevance, accuracy of content, and balance of presentation by Robert A. Schwartz, MD, MPH, Professor & Head, Dermatology, Professor of Medicine and of Pediatrics, Rutgers New Jersey Medical School, Newark, NJ.

Disclosure: Robert A. Schwartz, MD, MPH has disclosed no relevant financial relationships.

Field Testers

This activity has been pilot-tested for time required for participation by Steven M. Draikiwicz, MD and Daniel Grabell, MD.

The field testers have disclosed no relevant financial relationships.

CME / CE

Update on Female Pattern Hair Loss: Advances in Diagnosis and Treatment

Authors: Antonella Tosti, MD; Lakshi M. Aldrege, MSN, ANP-BC; Amy J. McMichael, MD
CME / CE Released: 2/28/2016
THIS ACTIVITY HAS EXPIRED FOR CREDIT
Valid for credit through: 2/28/2017, 11:59 PM EST

Start Activity

Target Audience and Goal Statement

This activity is intended for dermatologists, primary care providers, OB/GYNs, nurses, and pharmacists.

The goal of this activity is to provide clinicians with current perspectives on the identification and treatment of female pattern hair loss (FPHL) and communication strategies for patients with FPHL.

Upon completion of this activity, participants should be better able to:

Describe the prevalence, pathogenesis, diagnosis, and clinical presentation of female pattern hair loss
Outline the psychological and quality-of-life effects of hair loss in women and how these effects inform management strategies
Review the available treatments for female pattern hair loss

Disclosures

Faculty

Antonella Tosti, MD

Activity Chair and Professor, Department of Dermatology & Cutaneous Surgery, University of Miami, Miami, Florida

Disclosures

Disclosure: Antonella Tosti, MD has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Aclaris Therapeutics, Inc., DS Laboratories, Incyte Corporation, Kythera Biopharmaceuticals, Polichem, Procter & Gamble

Dr Tosti does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

Dr Tosti does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Lakshi M. Aldrege, MSN, ANP-BC

Nurse Practitioner, Dermatology Service, VA Portland Health Care System, Portland, Oregon

Disclosures

Disclosure: Lakshi M. Aldrege, NP has disclosed the following relevant financial relationships:
Served as a speaker or a member of a speakers bureau for: AbbVie Inc., Celgene Corporation, Eli Lilly and Company, Novartis Pharmaceuticals Corporation, Pfizer, Inc.

Ms Aldrege does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

Dr Aldrege does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Amy J. McMichael, MD

Professor, Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, North Carolina

Disclosures

Disclosure: Amy J. McMichael, MD has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Allergan, Covance Inc., eResearch Technology, Inc., Galderma Laboratories, LP, Guthey Renker, Incyte Corporation, Johnson & Johnson, KeraNetics LLC, Merck & Co., Inc., Merz Inc., Proctor & Gamble, Samumed, LLC
Received grants for clinical research from: Allergan, Proctor & Gamble, Samumed LLC
Other: Royalties from: Informa Healthcare, UpToDate

Dr McMichael does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

Dr McMichael does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Editor

Shari J. Dermer, PhD

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Shari J. Dermer, PhD has disclosed no relevant financial relationships.

CE Reviewer/Nurse Planner

Amy Bernard, MS, BSN, RN-BC

Lead Nurse Planner, Medscape, LLC

Disclosures

Disclosure: Amy Bernard, MS, BSN, RN-BC, has disclosed no relevant financial relationships.

Patrick Dwyer

Director, CME, Center for Continuing and Outreach Education at Rutgers Biomedical and Health Sciences

Disclosures

Disclosure: Patrick Dwyer has disclosed no relevant financial relationships.

Peer Reviewer

Field Testers

This activity has been pilot-tested for time required for participation by Steven M. Draikiwicz, MD and Daniel Grabell, MD.

The field testers have disclosed no relevant financial relationships.

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Rutgers, The State University of New Jersey designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Medscape designates this continuing education activity for 1.00 contact hour(s) (0.100 CEUs) (Universal Activity Number: 0461-9999-16-050-H01-P)

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From Medscape Education Dermatology

CME / CE

Update on Female Pattern Hair Loss: Advances in Diagnosis and Treatment

Authors: Antonella Tosti, MD; Lakshi M. Aldrege, MSN, ANP-BC; Amy J. McMichael, MDFaculty and Disclosures

THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / CE Released: 2/28/2016

Valid for credit through: 2/28/2017, 11:59 PM EST

processing....

Abbreviations

AA = alopecia areata
CA = cicatricial alopecia
CBC = complete blood count
CTE = chronic telogen effluvium
DHEAS = dehydroepiandrosterone sulfate
FDA = US Food and Drug Administration
FPHL = female pattern hair loss
HCG = human chorionic gonadotropin
PCOS = polycystic ovary syndrome
QoL = quality of life
TE = telogen effluvium

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References

Faculty and Disclosures

Faculty

Antonella Tosti, MD

Lakshi M. Aldrege, MSN, ANP-BC

Amy J. McMichael, MD

Editor

Shari J. Dermer, PhD

CE Reviewer/Nurse Planner

Amy Bernard, MS, BSN, RN-BC

Patrick Dwyer

Peer Reviewer

Field Testers

CME / CE

Update on Female Pattern Hair Loss: Advances in Diagnosis and Treatment

Target Audience and Goal Statement

Disclosures

Faculty

Antonella Tosti, MD

Lakshi M. Aldrege, MSN, ANP-BC

Amy J. McMichael, MD

Editor

Shari J. Dermer, PhD

CE Reviewer/Nurse Planner

Amy Bernard, MS, BSN, RN-BC

Patrick Dwyer

Peer Reviewer

Field Testers

Accreditation Statements

For Physicians

For Nurses

For Pharmacists

Instructions for Participation and Credit

Update on Female Pattern Hair Loss: Advances in Diagnosis and Treatment

Abbreviations