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CME

Treatment of Thromboembolic Disease: The Need for Multiple Perspectives

  • Authors: Jeffrey I. Weitz, MD; Alex C. Spyropoulos, MD; Mark A. Crowther, MD, MSc; Jan Beyer-Westendorf, MD; Rupert M. Bauersachs, MD; Philip S. Wells, MD, MSc.
  • CME Released: 8/20/2015
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 8/20/2016
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Target Audience and Goal Statement

This activity is intended for cardiologists, neurologists, internal medicine physicians, and other healthcare professionals involved in the prevention and treatment of thromboembolic disorders.

Non-vitamin K antagonist oral anticoagulants are now being widely used across the spectrum of thromboembolic disorders. The goal of this activity is to provide practical information on how to manage these agents in a variety of clinical settings.

Upon completion of this activity, participants will be able to:

  1. Review the use of non-vitamin K antagonist oral anticoagulants (NOACs) in real-world clinical settings
  2. Discuss the management of bleeding events and anticoagulation strategies with regard to surgical procedures for patients taking NOACs
  3. Discuss the use of NOACs in patients with cancer and for long-term prevention of venous thromboembolism


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Author(s)

  • Jeffrey I. Weitz, MD, FRACP

    Professor of Medicine and Biochemistry, McMaster University; Executive Director, Thrombosis & Atherosclerosis Research Institute, Hamilton, Ontario, Canada

    Disclosures

    Disclosure: Jeffrey I. Weitz, MD, FRCPC, has disclosed the following relevant financial information:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Isis Pharmaceuticals, Inc.; Janssen Pharmaceuticals, Inc.; Pfizer Inc; Portola Pharmaceuticals, Inc.

    Dr Weitz does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Weitz does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Alex C. Spyropoulos, MD

    Director, Anticoagulation and Clinical Thrombosis Services, North Shore-LIJ Health System; Professor of Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, New York, United States

    Disclosures

    Disclosure: Alex C. Spyropoulos, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Janssen Pharmaceuticals; Pfizer Inc.

    Dr Spyropoulos does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Spyropoulos does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Mark A. Crowther, MD, MSc

    Professor, Pathology and Molecular Medicine, Medicine and Clinical Epidemiology and Biostatistics; Chair, Department of Pathology and Molecular Medicine; Leo Pharma Chair in Thromboembolism Research, McMaster University, Hamilton, Ontario, Canada

    Disclosures

    Disclosure: Mark A. Crowther, MD, FRCPC, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Octapharma; Janssen Pharmaceuticals, Inc.; LEO Pharma Inc.; Pfizer Inc.; Portola Pharmaceuticals, Inc.
    Received grants for clinical research from: Bayer AG; Heart and Stroke Foundation of Canada; LEO Pharma Inc.

    Dr Crowther, does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Crowther, does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Jan Beyer-Westendorf, MD

    Professor, Head of Thrombosis Research, Center for Vascular Diseases, University Hospital Carl Gustav Carus, Dresden, Germany

    Disclosures

    Disclosure: Jan Beyer-Westendorf, PD, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Daiichi Sankyo, Inc.; Pfizer Inc
    Served as a speaker or a member of a speakers' bureau for: Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals, Inc., Daiichi Sankyo, Inc.; Pfizer Inc
    Received grants for clinical research from: Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals, Inc.;Daiichi Sankyo, Inc.; Pfizer Inc

    Jan Beyer-Westendorf, MD, does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Jan Beyer-Westendorf, MD, does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Rupert M. Bauersachs, MD

    Professor and Doctor, Vascular Medicine, Klinikum Damstadt GmbH, Darmstadt, Germany

    Disclosures

    Disclosure: Rupert M. Bauersachs, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Pfizer Inc
    Served as a speaker or a member of a speakers bureau for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Pfizer Inc
    Received grants for clinical research from: Bayer HealthCare Pharmaceuticals; Pfizer Inc

    Dr Bauersachs does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Bauersachs does not intend to discuss investigational uses of drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Philip S. Wells, MD, MSc, FRCPC

    Professor, Chief, and Chair, Department of Medicine, The Ottawa Hospital and the University of Ottawa, Ottawa, Ontario, Canada

    Disclosures

    Disclosure: Philip S. Wells, MD, MSc, FRCPC, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals
    Served as a speaker or a member of a speakers bureau for: Bayer HealthCare Pharmaceuticals
    Received grants for clinical research from: Bristol-Myers Squibb Company; Pfizer Inc

    Dr Wells does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Wells does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Steering Committee

  • Keith A. A. Fox, MB, ChB

    Professor of Cardiology, Centre for Cardiovascular Science; University of Edinburgh, Edinburgh, United Kingdom

    Disclosures

    Disclosure: Keith A. A. Fox, MB, ChB, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Lilly; Sanofi
    Served as a speaker or a member of a speakers bureau for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; Janssen Pharmaceuticals, Inc.
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Lilly

  • Dan Atar, MD

    Professor and Head, Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway

    Disclosures

    Disclosure: Dan Atar, MD, has disclosed the following relevant financial relationships: Dan Atar, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Cardiome Pharma Corp.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Merck & Co., Inc.; Nycomed; Pfizer Inc; Sanofi; Takeda Pharmaceuticals North America, Inc.

  • Lord Ajay K. Kakkar, MD, PhD

    Director, Thrombosis Research Institute; Professor of Surgery, University College London, London, United Kingdom

    Disclosures

    Disclosure: Lord Ajay K. Kakkar, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Daiichi Sankyo, Inc.; Sanofi
    Received grants for clinical research from: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.

  • Jessica L. Mega, MD, MPH

    Cardiologist, Brigham and Women's Hospital; Investigator, TIMI Study Group; Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts

    Disclosures

    Disclosure: Jessica L. Mega, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: American Genomics; Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Janssen Pharmaceuticals, Inc.; Portola Pharmaceuticals, Inc.
    Received grants for clinical research from: Accumetrics, Inc.; Bayer HealthCare Pharmaceuticals; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Lilly; Nanosphere, Inc.; Sanofi

  • P. Gabriel Steg, MD

    Professor, Department of Cardiology; Director, Coronary Care Unit, Hôpital Bichat-Claude Bernard, Service de Cardiologie; Faculté de Médecine Xavier Bichat, Université de Paris XII, Paris, France

    Disclosures

    Disclosure: P. Gabriel Steg, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Amarin Corporation plc; AstraZeneca Pharmaceuticals LP; Bayer Healthcare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Lilly; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; Otsuka Pharmaceutical Co., Ltd; Pfizer Inc; Regado Biosciences; Roche; Sanofi; SERVIER; The Medicines Company; VIVUS Inc.
    Received grants for clinical research from: Sanofi; SERVIER
    Owns stock, stock options, or bonds from: Aterovax

  • Alexander G. G. Turpie, MD

    Professor of Medicine, McMaster University, Hamilton, Ontario, Canada

    Disclosures

    Disclosure: Alexander G. G. Turpie, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Portola Pharmaceuticals, Inc.
    Served as a speaker or a member of a speakers bureau for: Bristol-Myers Squibb Company; GlaxoSmithKline; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Pfizer Inc

Editor

  • Caroline M. Padbury, B.Pharm

    Lead Scientific Director, Medscape LLC

    Disclosures

    Disclosure: Caroline M. Padbury, B.Pharm, has disclosed no relevant financial relationships.

CME Reviewer

  • Amy Bernard, MS, BSN, RN-BC

    Lead Nurse Planner, Medscape, LLC

    Disclosures

    Disclosure: Amy Bernard, MS, BSN, RN-BC, has disclosed no relevant financial relationships.

Peer Reviewer

Received grants for clinical research from: Otsuka Pharmaceutical Co., Ltd.
Served as an advisor or consultant for: HeartWare International, Inc.; Thoratec Corporation


Accreditation Statements

    For Physicians

  • Medscape, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Medscape, LLC staff have disclosed that they have no relevant financial relationships.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


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There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
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You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

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CME

Treatment of Thromboembolic Disease: The Need for Multiple Perspectives

Authors: Jeffrey I. Weitz, MD; Alex C. Spyropoulos, MD; Mark A. Crowther, MD, MSc; Jan Beyer-Westendorf, MD; Rupert M. Bauersachs, MD; Philip S. Wells, MD, MSc.Faculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME Released: 8/20/2015

Valid for credit through: 8/20/2016

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