Target Audience and Goal Statement
This activity is intended for cardiologists, neurologists, internal medicine physicians, and other healthcare professionals
involved in the prevention and treatment of thromboembolic disorders.
Non-vitamin K antagonist oral anticoagulants are now being widely used across the spectrum of thromboembolic disorders. The
goal of this activity is to provide practical information on how to manage these agents in a variety of clinical settings.
Upon completion of this activity, participants will be able to:
- Review the use of non-vitamin K antagonist oral anticoagulants (NOACs) in real-world clinical settings
- Discuss the management of bleeding events and anticoagulation strategies with regard to surgical procedures for patients taking
NOACs
- Discuss the use of NOACs in patients with cancer and for long-term prevention of venous thromboembolism
Disclosures
As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of
an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant
financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial
relationships of a spouse or life partner, that could create a conflict of interest.
Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food
and Drug Administration, at first mention and where appropriate in the content.
Author(s)

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Jeffrey I. Weitz, MD, FRACP
Professor of Medicine and Biochemistry, McMaster University; Executive Director, Thrombosis & Atherosclerosis Research Institute,
Hamilton, Ontario, Canada
Disclosures
Disclosure: Jeffrey I. Weitz, MD, FRCPC, has disclosed the following relevant financial information:
Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers
Squibb Company; Daiichi Sankyo, Inc.; Isis Pharmaceuticals, Inc.; Janssen Pharmaceuticals, Inc.; Pfizer Inc; Portola Pharmaceuticals,
Inc.
Dr Weitz does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.
Dr Weitz does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

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Alex C. Spyropoulos, MD
Director, Anticoagulation and Clinical Thrombosis Services, North Shore-LIJ Health System; Professor of Medicine, Hofstra
North Shore-LIJ School of Medicine, Hempstead, New York, United States
Disclosures
Disclosure: Alex C. Spyropoulos, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Janssen Pharmaceuticals; Pfizer
Inc.
Dr Spyropoulos does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.
Dr Spyropoulos does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

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Mark A. Crowther, MD, MSc
Professor, Pathology and Molecular Medicine, Medicine and Clinical Epidemiology and Biostatistics; Chair, Department of Pathology
and Molecular Medicine; Leo Pharma Chair in Thromboembolism Research, McMaster University, Hamilton, Ontario, Canada
Disclosures
Disclosure: Mark A. Crowther, MD, FRCPC, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Octapharma; Janssen Pharmaceuticals,
Inc.; LEO Pharma Inc.; Pfizer Inc.; Portola Pharmaceuticals, Inc.
Received grants for clinical research from: Bayer AG; Heart and Stroke Foundation of Canada; LEO Pharma Inc.
Dr Crowther, does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.
Dr Crowther, does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

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Jan Beyer-Westendorf, MD
Professor, Head of Thrombosis Research, Center for Vascular Diseases, University Hospital Carl Gustav Carus, Dresden, Germany
Disclosures
Disclosure: Jan Beyer-Westendorf, PD, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Daiichi
Sankyo, Inc.; Pfizer Inc
Served as a speaker or a member of a speakers' bureau for: Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals,
Inc., Daiichi Sankyo, Inc.; Pfizer Inc
Received grants for clinical research from: Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals, Inc.;Daiichi
Sankyo, Inc.; Pfizer Inc
Jan Beyer-Westendorf, MD, does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.
Jan Beyer-Westendorf, MD, does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

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Rupert M. Bauersachs, MD
Professor and Doctor, Vascular Medicine, Klinikum Damstadt GmbH, Darmstadt, Germany
Disclosures
Disclosure: Rupert M. Bauersachs, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers
Squibb Company; Daiichi Sankyo, Inc.; Pfizer Inc
Served as a speaker or a member of a speakers bureau for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals,
Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Pfizer Inc
Received grants for clinical research from: Bayer HealthCare Pharmaceuticals; Pfizer Inc
Dr Bauersachs does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.
Dr Bauersachs does not intend to discuss investigational uses of drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

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Philip S. Wells, MD, MSc, FRCPC
Professor, Chief, and Chair, Department of Medicine, The Ottawa Hospital and the University of Ottawa, Ottawa, Ontario, Canada
Disclosures
Disclosure: Philip S. Wells, MD, MSc, FRCPC, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals
Served as a speaker or a member of a speakers bureau for: Bayer HealthCare Pharmaceuticals
Received grants for clinical research from: Bristol-Myers Squibb Company; Pfizer Inc
Dr Wells does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.
Dr Wells does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.
Steering Committee
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Keith A. A. Fox, MB, ChB
Professor of Cardiology, Centre for Cardiovascular Science; University of Edinburgh, Edinburgh, United Kingdom
Disclosures
Disclosure: Keith A. A. Fox, MB, ChB, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; GlaxoSmithKline;
Janssen Pharmaceuticals, Inc.; Lilly; Sanofi
Served as a speaker or a member of a speakers bureau for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals;
Janssen Pharmaceuticals, Inc.
Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare Pharmaceuticals; GlaxoSmithKline;
Janssen Pharmaceuticals, Inc.; Lilly
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Dan Atar, MD
Professor and Head, Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway
Disclosures
Disclosure: Dan Atar, MD, has disclosed the following relevant financial relationships: Dan Atar, MD, has disclosed the following
relevant financial relationships:
Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Cardiome
Pharma Corp.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Merck & Co., Inc.; Nycomed; Pfizer Inc; Sanofi; Takeda Pharmaceuticals
North America, Inc.
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Lord Ajay K. Kakkar, MD, PhD
Director, Thrombosis Research Institute; Professor of Surgery, University College London, London, United Kingdom
Disclosures
Disclosure: Lord Ajay K. Kakkar, MD, PhD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Daiichi
Sankyo, Inc.; Sanofi
Received grants for clinical research from: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.
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Jessica L. Mega, MD, MPH
Cardiologist, Brigham and Women's Hospital; Investigator, TIMI Study Group; Associate Professor of Medicine, Harvard Medical
School, Boston, Massachusetts
Disclosures
Disclosure: Jessica L. Mega, MD, MPH, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: American Genomics; Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals,
Inc.; Janssen Pharmaceuticals, Inc.; Portola Pharmaceuticals, Inc.
Received grants for clinical research from: Accumetrics, Inc.; Bayer HealthCare Pharmaceuticals; Bristol-Myers Squibb Company;
Daiichi Sankyo, Inc.; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Lilly; Nanosphere, Inc.; Sanofi
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P. Gabriel Steg, MD
Professor, Department of Cardiology; Director, Coronary Care Unit, Hôpital Bichat-Claude Bernard, Service de Cardiologie; Faculté de Médecine Xavier Bichat, Université de Paris XII, Paris, France
Disclosures
Disclosure: P. Gabriel Steg, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Amarin Corporation plc; AstraZeneca Pharmaceuticals LP; Bayer Healthcare Pharmaceuticals;
Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; GlaxoSmithKline; Janssen Pharmaceuticals,
Inc.; Lilly; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; Otsuka Pharmaceutical Co., Ltd; Pfizer Inc; Regado Biosciences;
Roche; Sanofi; SERVIER; The Medicines Company; VIVUS Inc.
Received grants for clinical research from: Sanofi; SERVIER
Owns stock, stock options, or bonds from: Aterovax
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Alexander G. G. Turpie, MD
Professor of Medicine, McMaster University, Hamilton, Ontario, Canada
Disclosures
Disclosure: Alexander G. G. Turpie, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Portola
Pharmaceuticals, Inc.
Served as a speaker or a member of a speakers bureau for: Bristol-Myers Squibb Company; GlaxoSmithKline; Johnson & Johnson
Pharmaceutical Research & Development, L.L.C.; Pfizer Inc
Editor
CME Reviewer
Peer Reviewer
Received grants for clinical research from: Otsuka Pharmaceutical Co., Ltd.
Served as an advisor or consultant for: HeartWare International, Inc.; Thoratec Corporation
Accreditation Statements
For Physicians
-
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education for physicians.
Medscape, LLC designates this enduring material for a maximum of 0.50
AMA PRA Category 1 Credit(s)™
. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Medscape, LLC staff have disclosed that they have no relevant financial relationships.
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