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CME

Understanding GBCAs to Optimize Outcomes

  • Authors: Jeffrey C. Weinreb, MD; Bobby Kalb, MD; Eugene Duke, MD; Diego R. Martin, MD, PhD; Shaun R. Best, MD; Vu Luong, MD; Claude Sirlin, MD
  • CME Released: 5/26/2015; Reviewed and Renewed: 5/26/2017
  • THIS ACTIVITY HAS EXPIRED
  • Valid for credit through: 5/26/2018
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Target Audience and Goal Statement

This activity is intended for radiologists, oncologists, pediatricians, neurologists, cardiologists, hepatologists, and gastroenterologists.

The goal of this activity is to explore the role of gadolinium-based contrast agents (GBCAs) in the body and their application in magnetic resonance imaging (MRI).

Upon completion of this activity, participants will be able to:

  1. Identify the properties of GBCAs that make them suitable for MRI
  2. Compare properties of MRI contrast agents that influence their behavior in clinical applications and contribute to safety
  3. Explain the function of gadolinium in the body during MRI


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Authors

  • Jeffrey C. Weinreb, MD

    Professor of Diagnostic Radiology; Director, MRI Service, Yale School of Medicine, New Haven, Connecticut

    Disclosures

    Disclosure: Jeffrey C. Weinreb, MD, has disclosed no relevant financial relationships.

    Dr Weinreb does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Weinreb does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Bobby Kalb, MD

    Associate Professor of Radiology, Department of Medical Imaging, University of Arizona College of Medicine, Tucson, Arizona

    Disclosures

    Disclosure: Bobby Kalb, MD, has disclosed no relevant financial relationships.

    Dr Kalb does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Kalb does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Eugene Duke, MD

    Clinical Assistant, Department of Radiology, University of Arizona College of Medicine, Tucson, Arizona

    Disclosures

    Disclosure: Eugene Duke, MD, has disclosed no relevant financial relationships.

    Dr Duke does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Duke does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Diego R. Martin, MD, PhD

    Professor of Medicine; Head, Department of Medical Imaging, University of Arizona College of Medicine, Tucson, Arizona

    Disclosures

    Disclosure: Diego R. Martin, MD, PhD, has disclosed no relevant financial relationships.

    Dr Martin does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Martin does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Shaun R. Best, MD

    Fellow Physician, Department of Radiology, University of California, San Diego, La Jolla, California

    Disclosures

    Disclosure: Shaun R. Best, MD, has disclosed no relevant financial relationships.

    Dr Best does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Best does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Vu Luong, MD

    Fellow, Department of Radiology, University of California, San Diego

    Disclosures

    Disclosure: Vu Luong, MD, has disclosed no relevant financial relationships.

    Dr Luong does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Luong does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Claude B. Sirlin, MD

    Professor of Radiology; Chief, Body Imaging and Abdominal MRI; Director, Liver Imaging Group, University of California, San Diego

    Disclosures

    Disclosure: Claude B. Sirlin, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; VirtualScopics
    Served as a speaker or a member of a speakers bureau for: Bayer HealthCare Pharmaceuticals
    Received grants for clinical research from: GE Healthcare; Pfizer Inc; Siemens Healthcare Diagnostics Inc.

    Dr Sirlin does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Sirlin does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Steering Committee

  • William G. Bradley Jr, MD, PhD

    Professor and Chair, Department of Radiology, University of California, San Diego

    Disclosures

    Disclosure: William G. Bradley Jr, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Time Medical Systems, Inc.

  • Gillian M. Newstead, MD

    Professor of Radiology (Retired); Director, Global Breast Imaging, University of Chicago, Chicago, Illinois

    Disclosures

    Disclosure: Gillian M. Newstead, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Three Palm Software LLC
    Received grants for clinical research from: Bayer HealthCare Pharmaceuticals; Philips Healthcare

  • Shreyas Vasanawala, MD, PhD

    Associate Professor of Radiology, Stanford School of Medicine, Stanford, California

    Disclosures

    Disclosure: Shreyas Vasanawala, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Arterys
    Received grants for clinical research from: GE Healthcare

Editor

  • Charlotte Warren

    Scientific Director, Medscape, LLC

    Disclosures

    Disclosure: Charlotte Warren has disclosed no relevant financial relationships.

Bulk Contributor(s)

CME Reviewer

  • Nafeez Zawahir, MD

    CME Clinical Director, Medscape, LLC

    Disclosures

    Disclosure: Nafeez Zawahir, MD, has disclosed no relevant financial relationships.


Accreditation Statements

    For Physicians

  • Medscape, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Medscape, LLC designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Medscape, LLC staff have disclosed that they have no relevant financial relationships.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME

Understanding GBCAs to Optimize Outcomes

Authors: Jeffrey C. Weinreb, MD; Bobby Kalb, MD; Eugene Duke, MD; Diego R. Martin, MD, PhD; Shaun R. Best, MD; Vu Luong, MD; Claude Sirlin, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED

CME Released: 5/26/2015; Reviewed and Renewed: 5/26/2017

Valid for credit through: 5/26/2018

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Contents of This CME Activity

All sections of this activity are required for credit.

Section 1. Overview of GBCAs: From the Molecular Level Up
Dr Weinreb reviews the properties of GBCAs.
Jeffrey C. Weinreb, MD
Section 2. Safety of GBCAs
Drs Kalb, Martin, and Duke examine the risks for nephrogenic systemic fibrosis and anaphylactic shock associated with GBCAs, as well as safety when used during pregnancy.
Bobby Kalb, MD; Eugene Duke, MD; Diego R. Martin, MD, PhD
Section 3. Clinical Applications and Considerations for the Use of GBCAs in MRI of the Liver
Experts discuss the complicated processes associated with imaging the liver.
Shaun R. Best, MD; Vu Luong, MD; Claude Sirlin, MD

Educational Impact Challenge

Assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.