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CME

Advances in Rheumatoid Arthritis Treatments: From Pathophysiology to Treatment Options

  • Authors: Joel M. Kremer, MD
  • CME Released: 3/27/2015
  • THIS ACTIVITY HAS EXPIRED
  • Valid for credit through: 3/27/2016
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Target Audience and Goal Statement

This activity is intended for rheumatologists, internal medicine physicians, and other clinicians who treat patients with rheumatoid arthritis (RA).

Among rheumatologists, internal medicine physicians, and other clinicians who treat patients with RA, responses to educational activity surveys and tests point to an inadequate understanding of the immune pathophysiology of disease, the role of cytokines in the RA inflammatory cascade, and the rationale for targeted therapies with novel mechanisms of action (MOAs). This gap in knowledge leads to a lack of competence/confidence among clinicians in advancing appropriate, MOA-driven interventions in a timely manner. To address the identified educational needs among clinicians who treat patients with RA in the UAB Health System and nationwide, this initiative provides expert perspective on the pathophysiology of RA, the MOAs of emerging therapies, and the role of these targeted therapies in optimizing outcomes for patients with RA. The initiative is designed as a curriculum that promotes learning through a comprehensive educational plan with a reinforcement component and offline resources.

Upon completion of this activity, participants will be able to:

  1. Recognize the mechanisms of action of emerging RA therapies within the immune cascade
  2. Identify anticipated benefits of therapy based on target components
  3. Assess the safety and efficacy of novel therapies for RA that target underlying pathophysiology to achieve treatment goals in patients with RA


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Author

  • Joel M. Kremer, MD

    Pfaff Family Professor of Medicine, Albany Medical College; Director of Research, Center for Rheumatology, Albany, New York; CMO, Corrona International, LLC.

    Disclosures

    Disclosure: Joel M. Kremer, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for:
    Served as a speaker or a member of a speakers bureau for: Corrona International, LLC
    Received grants for clinical research from: AbbVie Inc.; Bristol-Myers Squibb Company; Genentech, Inc.; Lilly; Pfizer Inc
    Owns stock, stock options, or bonds from: Corrona International, LLC
    Other: Board member of: Corrona International, LLC

    Dr Kremer does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Kremer does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Editor

  • Emilie McCardell

    Scientific Director, Medscape, LLC

    Disclosures

    Disclosure: Emilie McCardell has disclosed no relevant financial relationships.

CME/Content Reviewer

  • Nafeez Zawahir, MD

    CME Clinical Director, Medscape, LLC

    Disclosures

    Disclosure: Nafeez Zawahir, MD, has disclosed no relevant financial relationships.

Course Director and Editor

  • Jeffrey R. Curtis, MD, MPH – Course Chair

    William J. Koopman Professor of Medicine at the University of Alabama at Birmingham School of Medicine, Director, Arthritis Clinical Intervention Program (ACIP), Associate Director, Center for Education and Research on Therapeutics of Musculoskeletal Disorders (CERTS)

    Disclosures

    Disclosure: Jeffrey R. Curtis, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AbbVie Inc.; Amgen Inc.; Bristol-Myers Squibb Company; CORRONA, Inc.; Crescendo Biologics; Genentech, Inc.; Janssen Pharmaceuticals, Inc.; Pfizer Inc; Roche; UCB, Inc.
    Received grants for clinical research from: AbbVie Inc.; Amgen Inc.; Bristol-Myers Squibb Company; CORRONA, Inc.; Crescendo Biologics; Genentech, Inc.; Janssen Pharmaceuticals, Inc.; Pfizer Inc; Roche; UCB, Inc.


Accreditation Statements

    For Physicians

  • The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    The University of Alabama School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME

Advances in Rheumatoid Arthritis Treatments: From Pathophysiology to Treatment Options

Authors: Joel M. Kremer, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED

CME Released: 3/27/2015

Valid for credit through: 3/27/2016

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  • Joel Kremer, MD: Hello, I am Dr Joel Kremer, Pfaff Family Professor of Medicine at Albany Medical College and director of research at the Center for Rheumatology and chief medical officer (CMO) of Corrona, Inc. Our program today is titled "Advances in the Treatment of Rheumatoid Arthritis: From Pathophysiology to Treatment Options."

    I would like to mention that this program will include a discussion of off-label treatment options. In addition, this program will include a discussion of investigational agents, devices, or diagnostics not approved by the US Food and Drug Administration (FDA) for use in the United States.

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    Slide 1.

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Educational Impact Challenge

Assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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