Wednesday, October 4, 2023
As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.
Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.
Pfaff Family Professor of Medicine, Albany Medical College; Director of Research, Center for Rheumatology, Albany, New York; CMO, Corrona International, LLC.
This activity is intended for rheumatologists, internal medicine physicians, and other clinicians who treat patients with rheumatoid arthritis (RA).
Among rheumatologists, internal medicine physicians, and other clinicians who treat patients with RA, responses to educational activity surveys and tests point to an inadequate understanding of the immune pathophysiology of disease, the role of cytokines in the RA inflammatory cascade, and the rationale for targeted therapies with novel mechanisms of action (MOAs). This gap in knowledge leads to a lack of competence/confidence among clinicians in advancing appropriate, MOA-driven interventions in a timely manner. To address the identified educational needs among clinicians who treat patients with RA in the UAB Health System and nationwide, this initiative provides expert perspective on the pathophysiology of RA, the MOAs of emerging therapies, and the role of these targeted therapies in optimizing outcomes for patients with RA. The initiative is designed as a curriculum that promotes learning through a comprehensive educational plan with a reinforcement component and offline resources.
Upon completion of this activity, participants will be able to:
As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.
Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.
Pfaff Family Professor of Medicine, Albany Medical College; Director of Research, Center for Rheumatology, Albany, New York; CMO, Corrona International, LLC.
The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The University of Alabama School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]
There are no fees for participating in or receiving credit for this online educational activity. For information on applicability
and acceptance of continuing education credit for this activity, please consult your professional licensing board.
This activity is designed to be completed within the time designated on the title page; physicians should claim only those
credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the
activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.
Follow these steps to earn CME/CE credit*:
You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it.
Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print
out the tally as well as the certificates from the CME/CE Tracker.
*The credit that you receive is based on your user profile.
CME Released: 3/27/2015
Valid for credit through: 3/27/2016, 11:59 PM EST
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ACPA = anti-citrullinated protein antibody
ACR = American College of Rheumatology
AE = adverse events
BID = twice a day
CDAI = Clinical Disease Activity Index
CMO = Chief Medical Officer
CRP = C-reactive protein
DARWIN 1 = Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Patients
DARWIN 2 = Dose-finding Study of GLPG0634 as Monotherapy in Active Rheumatoid Arthritis (RA) Patients
DAS28 = Disease Activity Score in 28 joints
DMARD = disease-modifying antirheumatic drug
ESR = erythrocyte sedimentation rate
EULAR = European League Against Rheumatism
FDA = US Food and Drug Administration
GM-CSF = granulocyte-macrophage colony-stimulating factor
gp = glycoprotein
H2O2 = hydrogen peroxide
HAQ-DI = Health Assessment Questionnaire for Rheumatoid Arthritis
HPA = hypothalamic-pituitary-adrenal (axis)
IL -1/6/17 = interleukin 1/6/17
IR = inadequate response
IV = intravenous
JAK = Janus kinase
MHC II = major histocompatibility complex class II
MMP = matrix metalloproteinase
MOA = mechanism of action
MTX = methotrexate
qw = every week
q2w = every 2 weeks
RA = rheumatoid arthritis
RANKL = receptor activator of nuclear factor kappa-B ligand
RRF = rheumatoid factor
SAE = serious adverse event
SAR = sarilumab
SC = subcutaneous
SDAI = Simple Disease Activity Index
STANDARD = Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis study
STAT = signal transducer and activator of transcription
TCZ = tocilizumab
TEAE = treatment-emergent adverse event
TGF = transforming growth factor
TNF = tumor necrosis factor
TNFI = tumor necrosis factor inhibitor
Tyk2 = tyrosine kinase 2
VEGF = vascular endothelial growth factor
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