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CME

Rapid Rule Out of AMI: Taking Cardiac Testing to the Next Level

  • Authors: David Morrow, MD; Christian Mueller, MD; Bertil Lindahl, MD, PhD; Christopher R deFilippi, MD
  • CME Released: 1/22/2016
  • THIS ACTIVITY HAS EXPIRED
  • Valid for credit through: 1/22/2017
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Target Audience and Goal Statement

This activity is intended for cardiologists, emergency medicine physicians, and primary care physicians.

The goal of this activity is to help clinicians understand recent clinical trial data on the use biomarkers, such as high-sensitivity cardiac troponin levels, to rapidly exclude acute myocardial infarction (AMI).

Upon completion of this activity, participants will be able to:

  1. Evaluate the clinical need for tools and biomarkers that rapidly and reliably diagnose or rule out acute myocardial infarction
  2. Assess recent clinical trial data on the use of biomarkers such as hs-troponin to rapidly exclude AMI


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Moderator(s)

  • David A. Morrow, MD, MPH

    Associate Professor of Medicine, Harvard Medical School; Director, Levine Cardiac Intensive Care Unit, Brigham and Women's Hospital, Boston, Massachusetts

    Disclosures

    Disclosure: David A. Morrow, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: BG Medicine; Critical Diagnostics; Genentech, Inc.; Gilead Sciences, Inc.; Instrumentation Laboratory; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Merck & Co., Inc.; Roche Dignostics; SERVIER
    Received grants for clinical research from: Amgen, Inc.; AstraZeneca Pharmaceuticals LP; Athera Biotechnologies AB; Beckman Coulter, Inc.; BG Medicine; Bristol-Myers Squibb Company; BÜHLMANN Laboratories; Daichii Sankyo, Inc.; Eisai Co., Ltd; GlaxoSmithKline; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Lilly; Merck & Co., Inc.; Nanosphere, Inc.; Novartis Pharmaceuticals Corporation; Ortho-Clinical Diagnostics, Inc.; Pfizer Inc; Randox Laboratories Ltd.; Roche Diagnostics; Sanofi; Siemens AG; Singulex

    Dr Morrow does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Morrow does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Panelist(s)

  • Christian Mueller, MD

    Professor, University Hospital, Basel, Switzerland

    Disclosures

    Disclosure: Christian Mueller, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: BG Medicine; Brahms; Cardiorentis AG; Novartis Pharmaceuticals Corporation; Roche
    Served as a speaker or a member of a speakers bureau for: Abbott Laboratories; Brahms; Novartis Pharmaceuticals Corporation; Roche
    Received grants for clinical research from: Abbott Laboratories; Brahms; Roche; Siemens AG; Singulex

    Dr Mueller does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Mueller does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Bertil Lindahl, MD, PhD

    Professor, Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, Uppsala, Sweden

    Disclosures

    Disclosure: Bertil Lindahl, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: bioMérieux; Fiomi Diagnostics AB; Philips Healthcare; Roche
    Served as a speaker or a member of a speakers bureau for: Thermo Fisher Scientific Inc.
    Received grants for clinical research from: bioMérieux; Fiomi Diagnostics AB

    Dr Lindahl does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Lindahl does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Christopher deFilippi, MD

    Associate Professor of Medicine, University of Maryland School of Medicine, Baltimore, Maryland

    Disclosures

    Disclosure: Christopher deFilippi, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: HDL Therapeutics; Siemens AG; Roche Diagnostics
    Served as a speaker or a member of a speakers bureau for: Radiometer Medical ApS
    Received grants for clinical research from: Alere; BG Medicine; Critical Diagnostics; Roche Diagnostics

    Dr deFilippi does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr deFilippi does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Steering Committee

  • Ileana L. Piña, MD, MPH

    Professor of Medicine and Epidemiology & Population Health, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York

    Disclosures

    Disclosure: Ileana L. Piña, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: FDA; GE Healthcare; Novartis Pharmaceuticals Corporation
    Served as a speaker or a member of a speakers bureau for: Otsuka Pharmaceuticals

  • Gary Michael Felker, MD, MHS

    Associate Professor of Medicine; Chief-Heart Failure Section, Director-Clinical Research Unit, Director-Heart Failure Research, Duke University Medical Center, Durham, North Carolina

    Disclosures

    Disclosure: Gary Michael Felker, MD, MHS, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Amgen, Inc.; Celladon; Novartis Pharmaceuticals Corporation; Roche; Singulex; St Jude Medical; Trevana, Inc.; Zensun Sci. and Tech. Co., Ltd.
    Received grants for clinical research from: Amgen, Inc.; Roche; Otsuka Pharmaceuticals

  • W. Brian Gibler, MD

    Professor, Department of Emergency Medicine, University of Cincinnati College of Medicine; President and CEO, University of Cincinnati Medical Center, Cincinnati, Ohio

    Disclosures

    Disclosure: W. Brian Gibler, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Daiichi Sankyo, Inc.; Lilly
    Owns stock, stock options, or bonds from: Siloam Biosciences

  • Allan S. Jaffe, MD

    Professor of Medicine and Professor of Laboratory Medicine and Pathology, Mayo Clinic and Medical School; Consultant in Cardiology and Laboratory Medicine and Pathology and Chair, Clinical Laboratory Services, Mayo Clinic, Rochester, Minnesota

    Disclosures

    Disclosure: Allan S Jaffe, MD, has disclosed the following relevant financial information:
    Served as a speaker or a member of a speakers bureau for: Abbott Laboratories; Amgen, Inc.; Beckman Coulter, Inc.; Critical Diagnostics; diaDexus, Inc.; Ortho-Clinical Diagnostics; Radiometer Medical ApS; Roche

  • James L. Januzzi, MD

    Professor of Medicine, Harvard Medical School; Roman W. DeSanctis Endowed Clinical Scholar, Massachusetts General Hospital, Boston, Massachusetts

    Disclosures

    Disclosure: James L. Januzzi, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Critical Diagnostics; Roche
    Received grants for clinical research from: BG Medicine; Critical Diagnostics; Roche; Thermo Fisher Scientific Inc.

  • David A. Morrow, MD, MPH

    Disclosures

    As listed above.

  • L. Kristin Newby, MD, MHS

    Professor of Medicine, Cardiology, Duke University School of Medicine; Co-Director, Duke Cardiac Care Unit, Duke University Medical Center, Durham, North Carolina

    Disclosures

    Disclosure: L Kristin Newby, MD, MHS, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Daiichi Sankyo, Inc.; Genentech, Inc.; Janssen Pharmaceuticals Corporation, L.P.; Lilly; Navigant; Novartis Pharmaceuticals Corporation; Roche
    Received grants for clinical research from: Amylin Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; GlaxoSmithKline; Merck & Co., Inc.; Murdock Study; National Heart, Lung, and Blood Institute

Editor(s)

  • Joy Marko, MS, FNP-C, CCMEP

    Scientific Director, Medscape, LLC

    Disclosures

    Disclosure: Joy Marko, MS, FNP-C, CCMEP, has disclosed no relevant financial relationships.

CME Reviewer(s)

  • Nafeez Zawahir, MD

    CME Clinical Director, Medscape, LLC

    Disclosures

    Disclosure: Nafeez Zawahir, MD, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Received grants for clinical research from: Otsuka Pharmaceutical Co., Ltd.
Served as an advisor or consultant for: Thoratec Corporation; HeartWare International, Inc.


Accreditation Statements

    For Physicians

  • Medscape, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Medscape, LLC staff have disclosed that they have no relevant financial relationships.

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

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CME

Rapid Rule Out of AMI: Taking Cardiac Testing to the Next Level

Authors: David Morrow, MD; Christian Mueller, MD; Bertil Lindahl, MD, PhD; Christopher R deFilippi, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED

CME Released: 1/22/2016

Valid for credit through: 1/22/2017

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