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Endocrinological Insights Into Different in vitro Fertilization Treatment Aspects

  • Authors: Chun Ng, MRCOG; Geoffrey Trew, MRCOG
  • CME Released: 7/30/2012
  • Valid for credit through: 7/30/2013
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Target Audience and Goal Statement

This activity is intended for endocrinologists, obstetrician gynecologists, and other physicians who care for women with infertility.

The goal of this activity is to evaluate endocrine issues in IVF.

Upon completion of this activity, participants will be able to:

  1. Compare the use of gonadotropin-releasing hormone agonists and antagonists in IVF
  2. Analyze the use of gonadotropins in IVF
  3. Assess treatment of the luteal phase during IVF
  4. Evaluate other endocrine issues in IVF


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  • Chun Ng, MRCOG

    Consultant in Reproductive Medicine and Surgery, Hammersmith Hospital, London, United Kingdom


    Disclosure: Chun Ng, MRCOG, has disclosed no relevant financial relationships.

  • Geoffrey Trew, MRCOG

    Consultant in Reproductive Medicine and Surgery, Hammersmith Hospital, London, United Kingdom


    Disclosure: Geoffrey Trew, MRCOG, has disclosed no relevant financial relationships.


  • Elisa Manzotti

    Publisher, Future Science Group, London, United Kingdom


    Disclosure: Elisa Manzotti has disclosed no relevant financial relationships.

CME Author

  • Charles P. Vega, MD

    Health Sciences Clinical Professor; Residency Director, Department of Family Medicine, University of California, Irvine


    Disclosure: Charles P. Vega, MD, FAAFP, has disclosed no relevant financial relationships.

CME Reviewer

  • Nafeez Zawahir, MD

    CME Clinical Director, Medscape, LLC


    Disclosure: Nafeez Zawahir, MD, has disclosed no relevant financial relationships.

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    For Physicians

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    Medscape, LLC staff have disclosed that they have no relevant financial relationships.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

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Endocrinological Insights Into Different in vitro Fertilization Treatment Aspects

Authors: Chun Ng, MRCOG; Geoffrey Trew, MRCOGFaculty and Disclosures

CME Released: 7/30/2012

Valid for credit through: 7/30/2013



The science of reproductive endocrinology/in vitro fertilization (IVF) has moved forward considerably since the first IVF baby was born in 1978. IVF was originally indicated for women with tubal factor infertility, but it has now become the treatment for couples with unexplained subfertility, male subfertility, cervical factor, failed ovulation induction, endometriosis or unilateral tubal pathology. IVF was initially performed with the single dominant ovarian follicle produced during a spontaneous menstrual cycle. This was very inefficient and pregnancy rates were dismal. Consequently, superovulation protocols using parenteral gonadotrophins to induce maturation of multiple follicles were soon adopted worldwide. In addition, any supernumerary embryos remaining after embryo transfer may be cryopreserved for future embryo transfers without the need for another fresh IVF cycle. A greater understanding of IVF endocrinology has led to improved IVF pregnancy outcomes and satisfaction for the anxious parents. However, with the greater success of IVF treatment, new complications associated with the treatment arise, namely the ovarian hyperstimulation syndrome. Ovarian hyperstimulation can be associated with severe morbidity and may be even fatal. Ovarian hyperstimulation syndrome is an iatrogenic condition secondary to medical stimulation of the ovary, and was virtually unknown until IVF treatment was initiated. This article will discuss the recent developments in IVF treatment endocrinology and protocols, as well as prevention/treatment of its complications.