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CME

Balancing Safety and Efficacy in Appropriately Selected AF Patients

  • Authors: Robert J. Myerburg, MD; Stuart J. Connolly, MD
  • CME Released: 2/16/2012
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 2/16/2013, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for cardiologists, electrophysiologists, and other healthcare providers involved in the diagnosis and treatment of patients with atrial fibrillation.

The goal of this activity is to provide clinicians involved in the management of patients with atrial fibrillation with the knowledge necessary to implement new therapeutic paradigms into their clinical practices.

Upon completion of this activity, participants will be able to:

  1. Summarize recent FDA updates regarding the efficacy and safety of antiarrhythmic agents
  2. Describe approaches to tailor appropriate pharmacotherapy to an individual with paroxysmal and/or persistent atrial fibrillation
  3. Review strategies to reduce cardiovascular morbidity, mortality, and hospitalizations associated with paroxysmal and/or persistent atrial fibrillation


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Authors

  • Robert J. Myerburg, MD

    Professor of Medicine and Physiology, Miller School of Medicine, University of Miami, Miami, Florida

    Disclosures

    Disclosure: Robert J. Myerburg, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: GlaxoSmithKline; sanofi-aventis
    Served as a speaker or a member of a speakers bureau for: sanofi-aventis

    Dr. Myerburg does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the US Food and Drug Administration (FDA) for use in the United States.

    Dr. Myerburg does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Stuart J. Connolly, MD

    Professor of Medicine; Director of Cardiology, McMaster University, Hamilton General Hospital, McMaster Clinic, Hamilton, Ontario

    Disclosures

    Disclosure: Stuart J. Connolly, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Merck & Co., Inc.; Portola Pharmaceuticals, Inc.; sanofi-aventis
    Served as a speaker or a member of a speakers bureau for: Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Merck & Co., Inc.; Portola Pharmaceuticals, Inc.; sanofi-aventis
    Received grants for clinical research from: Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Merck & Co., Inc.; Portola Pharmaceuticals, Inc.; sanofi-aventis

    Dr. Connolly does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr. Connolly does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Editors

  • Ronald K. Miller, PhD

    Scientific Director, Medscape, LLC

    Disclosures

    Disclosure: Ronald K. Miller, PhD, has disclosed no relevant financial relationships.

  • Kathleen Walsh Tulley

    Clinical Editor, Medscape, LLC

    Disclosures

    Disclosure:  Kathleen Walsh Tulley has disclosed no relevant financial relationships.

Steering Committee

  • Anne B. Curtis, MD

    Disclosures

    Disclosure: Anne B. Curtis, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: sanofi-aventis; Medtronic, Inc.; Biosense Webster, Inc.; St. Jude Medical
    Served as a speaker or a member of a speakers bureau for: sanofi-aventis; Medtronic, Inc.
    Received grants for clinical research from: Medtronic, Inc.; St. Jude Medical

  • Jean-Marc Davy, MD

    Disclosures

    Disclosure: Jean-Marc Davy, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: sanofi-aventis; Boehringer Ingelheim Pharmaceuticals, Inc.; Medtronic, Inc.; Merck Sharp and Dohme; Novartis Pharmaceuticals Corporation
    Served as a speaker or a member of a speakers bureau for: sanofi-aventis; Boehringer Ingelheim Pharmaceuticals, Inc.; Medtronic, Inc.; Merck Sharp and Dohme; Novartis Pharmaceuticals Corporation
    Received grants for clinical research from: sanofi-aventis; Boehringer Ingelheim Pharmaceuticals, Inc.; Medtronic, Inc.; Merck Sharp and Dohme; Novartis Pharmaceuticals Corporation

  • Keith A. A. Fox, MB, ChB

    Disclosures

    Disclosure: Keith A. A. Fox, MB, ChB, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare Pharmaceuticals; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Eli Lilly and Company
    Received grants for clinical research from: Bayer HealthCare Pharmaceuticals; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Eli Lilly and Company

  • Paulus Kirchhof, MD

    Disclosures

    Disclosure: Paulus Kirchhof, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; 3M Medica; Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Boston Scientific; Omron Healthcare, Inc.; Meda Pharmaceuticals, Inc.; Medtronic, Inc.; sanofi-aventis; SERVIER; Siemens; Takeda Pharmaceuticals North America, Inc.; Bayer HealthCare Pharmaceuticals
    Received research grants for: 3M Medica; Meda Pharmaceuticals, Inc.; CV Therapeutics; Medtronic, Inc.; Omron Healthcare, Inc.; sanofi-aventis; St. Jude Medical

  • Gerald V. Naccarelli, MD

    Disclosures

    Disclosure: Gerald V. Naccarelli, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Daiichi Sankyo, Inc.; Blue Ash Therapeutics, LLC; Biosense Webster, Inc.; Ortho-McNeil-Janssen Pharmaceuticals, Inc.; Otsuka Pharmaceutical Co., Ltd.; St. Jude Medical; Bristol-Myers Squibb Company; Merck & Co., Inc.; Portola Pharmaceuticals, Inc.; Boehringer Ingelheim Pharmaceuticals, Inc.; Pfizer Inc.; AstraZeneca Pharmaceuticals LP; Medtronic, Inc.; sanofi-aventis; Gilead Sciences, Inc.; Novartis Pharmaceuticals Corporation; Xention; GlaxoSmithKline; BioCritique
    Received grants for clinical research from: GlaxoSmithKline; Boehringer Ingelheim Pharmaceuticals, Inc.; Astellas Pharma, Inc.

  • Carl J. Pepine, MD

    Disclosures

    Disclosure: Carl J. Pepine, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Abbott Laboratories; Amorcyte, Inc.; Angioblast Systems; Boehringer Ingelheim Pharmaceuticals, Inc.; Forest Laboratories, Inc.; Eli Lilly and Company; Medtelligence, LLC; NicOx; Novartis Pharmaceuticals Corporation; sanofi-aventis; SLACK Incorporated
    Received grants for clinical research from: GlaxoSmithKline; InfraReDx, Inc.; Pfizer Inc

  • Eric Prystowsky, MD

    Disclosures

    Disclosure: Eric N. Prystowsky, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Medtronic, Inc.; Boehringer Ingelheim Pharmaceuticals, Inc.; C. R. Bard, Inc.; sanofi-aventis; Stereotaxis, Inc.; CardioNet
    Served as a speaker or member of a speakers bureau for: BIOTRONIK
    Received grants for fellow training from: Medtronic, Inc.; Boston Scientific; St. Jude Medical
    Owns stock, stock options, or bonds from: CardioNet; Stereotaxis, Inc.

CME Reviewer

  • Nafeez Zawahir, MD

    CME Clinical Director, Medscape, LLC

    Disclosures

    Disclosure: Nafeez Zawahir, MD, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationship.


Accreditation Statements

    For Physicians

  • Medscape, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Medscape, LLC designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Medscape, LLC staff have disclosed that they have no relevant financial relationships.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME

Balancing Safety and Efficacy in Appropriately Selected AF Patients

Authors: Robert J. Myerburg, MD; Stuart J. Connolly, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME Released: 2/16/2012

Valid for credit through: 2/16/2013, 11:59 PM EST

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Abbreviations

AF = atrial fibrillation
AFFIRM = Atrial Fibrillation Follow-Up Investigation of Rhythm Management
ALT = alanine aminotransferase
ANDROMEDA = Antiarrhythmic Trial With Dronedarone in Moderate to Severe CHF Evaluating Morbidity Decrease
ATHENA = A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg bid for the Prevention of Cardiovascular Hospitalization or Death from Any Cause in Patients with Atrial Fibrillation/Atrial Flutter
CAD = coronary artery disease
CI = confidence interval
DIONYSOS = Efficacy and Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With AF
EMA = European Medicines Agency
FDA = US Food and Drug Administration
PALLAS = Permanent Atrial Fibrillation Outcome Study Using Dronedarone on Top of Standard Therapy

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