Table 1.

Cognitive Deficits Associated with Essential Tremor³⁴

Box 1.

Classic Concept of Essential Tremor

Box 2.

Essential Tremor: New Findings

Box 3.

Cognition in Patients with Essential Tremor

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Félix Bermejo-Pareja, MD, PhD

Department of Neurology, University Hospital "Doce de Octubre," Madrid, Spain

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CME

Essential Tremor -- A Neurodegenerative Disorder Associated With Cognitive Defects?

Authors: Félix Bermejo-Pareja, MD, PhD
CME Released: 4/12/2011
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This activity is intended for primary care clinicians, family practitioners, and other health professionals caring for patients with benign essential tremor.

The goal of this activity is to review the evidence that essential tremor may be a slowly progressive neurodegenerative disorder.

Upon completion of this activity, participants will be able to:

Describe cognitive and mood abnormalities in patients with essential tremor on the basis of review findings
Describe evidence for cerebellar and other pathology in patients with essential tremor on the basis of review findings
Describe recommended diagnostic workup in patients with essential tremor on the basis of review findings

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Author(s)

Félix Bermejo-Pareja, MD, PhD

Department of Neurology, University Hospital "Doce de Octubre," Madrid, Spain

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Disclosure: Félix Bermejo-Pareja, MD, PhD, has disclosed no relevant financial relationships.

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Heather Wood

Chief Editor, Nature Reviews Neurology

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Disclosure: Heather Wood has disclosed no relevant financial relationships.

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Laurie Barclay, MD

Freelance writer and reviewer, Medscape, LLC

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Disclosure: Laurie Barclay, MD, has disclosed no relevant financial relationships.

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Nafeez Zawahir, MD

CME Clinical Director, Medscape, LLC

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Disclosure: Nafeez Zawahir, MD, has disclosed no relevant financial relationships.

Sarah Fleischman

CME Program Manager, Medscape, LLC

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Key Points

Essential tremor was originally considered to be a monosymptomatic movement disorder without known CNS pathology
New research suggests that essential tremor is a slowly progressive neurodegenerative disorder predominantly associated with cerebellar pathology
Research indicates that patients with essential tremor commonly experience neurological abnormalities such as bradykinesia, ocular movement anomalies, deficits in hand-eye coordination, mild dysarthria, gait ataxia, and probably olfactory and hearing deficits
Essential tremor is associated with mild cognitive impairment and mood disorders including depression and anxiety, and also with an increased risk of dementia

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CME Information

References

References

Acknowledgments

Thanks to Dr J. Benito-León for his comments on the manuscript, V. Puertas-Martin for her advice on the neuropsychological data and to J. Healey for correcting many awkward English expressions in the manuscript.
L. Barclay, freelance writer and reviewer, is the author of and is solely responsible for the content of the learning objectives, questions and answers of the Medscape, LLC-accredited continuing medical education activity associated with this article.

Reprint Address

Department of Neurology, University Hospital "Doce de Octubre", Avenida de Cordoba s/n, Madrid 28041, Spain. Félix Bermejo-Pareja, MD, PhD [email protected] yahoo.es

Table 1.

Box 1.

Box 2.

Box 3.

CME

Essential Tremor -- A Neurodegenerative Disorder Associated With Cognitive Defects?

Target Audience and Goal Statement

Disclosures

Author(s)

Félix Bermejo-Pareja, MD, PhD

Editor(s)

Heather Wood

CME Author(s)

Laurie Barclay, MD

CME Reviewer(s)

Nafeez Zawahir, MD

Sarah Fleischman

Accreditation Statements

For Physicians

Instructions for Participation and Credit

Essential Tremor -- A Neurodegenerative Disorder Associated With Cognitive Defects?: Key Points

Key Points

Table of Contents

Acknowledgments

Reprint Address

Table 1.

Box 1.

Box 2.

Box 3.

References

Faculty and Disclosures

Author(s)

Félix Bermejo-Pareja, MD, PhD

Editor(s)

Heather Wood

CME Author(s)

Laurie Barclay, MD

CME Reviewer(s)

Nafeez Zawahir, MD

Sarah Fleischman

CME

Essential Tremor -- A Neurodegenerative Disorder Associated With Cognitive Defects?

Target Audience and Goal Statement

Disclosures

Author(s)

Félix Bermejo-Pareja, MD, PhD

Editor(s)

Heather Wood

CME Author(s)

Laurie Barclay, MD

CME Reviewer(s)

Nafeez Zawahir, MD

Sarah Fleischman

Accreditation Statements

For Physicians

Instructions for Participation and Credit

Essential Tremor -- A Neurodegenerative Disorder Associated With Cognitive Defects?: Key Points

Key Points

Table of Contents

Acknowledgments

Reprint Address