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Table 1.  

Differential Imaging Findings in Parkinsonian Syndromes

Table 2.  

Differential Imaging Findings in Dementias

Technology Insight: Imaging Neurodegeneration in Parkinson's Disease: Lewy Body Pathology in Parkinson's Disease


Lewy Body Pathology in Parkinson's Disease

In PD, the neurons that project from the lateral nigra to the posterior dorsal putamen are those most severely affected by Lewy body pathology.[2] It is often possible, however, to detect Lewy body inclusions in the anterior cingulate cortex and the frontal, parietal and temporal asso ciation areas at postmortem examination, even in patients who do not have dementia.[3] Currently, it remains unclear whether dementia with Lewy bodies (DLB), PD with later dementia (PDD), and PD without dementia all represent a spectrum of Lewy body disease. DLB has clinical features that overlap with those of Alzheimer’s disease (AD), and, at postmortem examination, most cases of DLB show a mixture of AD-like changes and cortical Lewy body inclusions.

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