Imaging Neurodegeneration in Parkinson's Disease

Table 1.

Differential Imaging Findings in Parkinsonian Syndromes

Table 2.

Differential Imaging Findings in Dementias

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Burn DJ et al. (1994) Differential diagnosis of Parkinson’s disease, multiple system atrophy, and Steele-Richardson-Olszewski syndrome: discriminant analysis of striatal ¹⁸F-dopa PET data. J Neurol Neurosurg Psychiatry 57: 278-284
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Eckert T et al. (2005) FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage 26: 912-921
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Key Points

Structural changes in the substantia nigra can be imaged with both transcranial sonography and MRI in patients with Parkinson's disease (PD), and are valuable for revealing susceptibility to PD
PET and single-photon emission CT measurements of dopamine terminal function are able to sensitively detect dopamine deficiency in both symptomatic patients and individuals at risk for parkinsonian syndromes; a normal scan in a patient suspected of having PD implies a good prognosis
Depression in PD does not seem to be of a serotonergic etiology; rather, it reflects a loss of noradrenergic and limbic monoaminergic function
Dementia with Lewy bodies can be reliably discriminated from Alzheimer’s disease by the detection of a loss of striatal dopamine transporter binding in the former
The majority of patients who have dementia with Lewy bodies have a substantial amyloid-β load, but this is rare in PD patients with late dementia
Atypical PD can be most sensitively discriminated from PD by use of Diffusion-weighted MRI or ¹⁸F-fluoro-2-deoxyglucose PET

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Acknowledgments

Désirée Lie, University of California, Irvine, CA, is the author of and is solely responsible for the content of the learning objectives, questions and answers of the Medscape-accredited continuing medical education activity associated with this article.

Reprint Address

David J Brooks, Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. Email: [email protected]

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Technology Insight: Imaging Neurodegeneration in Parkinson's Disease: Key Points

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Author(s)

David J Brooks, MD, DSc, FRCP, FMedSci

Editor(s)

Heather Wood

Technology Insight: Imaging Neurodegeneration in Parkinson's Disease: Key Points

Key Points

Table of Contents

Acknowledgments

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