Friday, September 29, 2023
This article is intended for primary care clinicians, gynecologists, endocrinologists, and other specialists who care for women.
The goal of this activity is to provide medical news to primary care clinicians and other healthcare professionals in order to enhance patient care.
Upon completion of this activity, participants will be able to:
As an organization accredited by the ACCME, Medscape, LLC requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.
Medscape, LLC encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.
Medscape, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Medscape, LLC designates this educational activity for a maximum of 0.25
AMA PRA Category 1 Credit(s)
™ . Physicians should only claim credit commensurate with the extent of their participation in the activity. Medscape Medical News has been reviewed and is acceptable for up to 200 Prescribed credits by the American Academy of Family Physicians. AAFP accreditation begins 09/01/06. Term of approval is for 1 year from this date. This activity is approved for 0.25 Prescribed credits. Credit may be claimed for 1 year from the date of this activity. AAFP credit is subject to change based on topic selection throughout the accreditation year.
For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]
There are no fees for participating in or receiving credit for this online educational activity. For information on applicability
and acceptance of continuing education credit for this activity, please consult your professional licensing board.
This activity is designed to be completed within the time designated on the title page; physicians should claim only those
credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the
activity online during the valid credit period that is noted on the title page.
Follow these steps to earn CME/CE credit*:
You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it.
Credits will be tallied in your CME/CE Tracker and archived for 5 years; at any point within this time period you can print
out the tally as well as the certificates by accessing "Edit Your Profile" at the top of your Medscape homepage.
*The credit that you receive is based on your user profile.
CME Released: 5/8/2007
Valid for credit through: 5/8/2008, 11:59 PM EST
processing....
May 8, 2007 — In nondiabetic women, menopause, but not age, is an independent risk factor for elevated fasting plasma glucose levels, according to the results of a study published in the May-June issue of Menopause.
"Glucose metabolism is influenced by various genetic and environmental factors," write Michio Otsuki, MD, from the Osaka University Graduate School of Medicine in Osaka, Japan, and colleagues. "In women the prevalence of abnormal glucose metabolism is known to increase around and after age 50. The aim of this study was to determine whether menopause augments fasting plasma glucose (FPG) levels in women."
Of 672 women in Japan undergoing health examinations, 505 did not have diabetes, had no history of hysterectomy, and had never used estrogens or progestins. All participants underwent an oral glucose tolerance test and recording of blood measurements and provided information about their menopausal status.
Of the 505 women, 208 were premenopausal and 297 were postmenopausal. Age, body mass index (BMI), triglyceride level, total cholesterol level, low-density lipoprotein (LDL) cholesterol level, blood pressure, and homeostasis model assessment insulin sensitivity index increased across quintiles of FPG levels. However, high-density lipoprotein (HDL) cholesterol level and homeostasis model assessment pancreatic β-cell function index were not correlated with FPG levels.
The number of premenopausal women decreased and the number of postmenopausal women increased across quintiles of FPG levels. Age, BMI, triglyceride level, LDL cholesterol level, and menopausal status were associated with FPG level, but HDL cholesterol level was not, based on univariate regression analysis. Independent risk factors for elevated FPG levels, based on stepwise multivariate regression analysis, were BMI, menopause, and triglyceride level, but age and LDL cholesterol level did not contribute to FPG levels.
"Menopause, but not age, is directly involved in augmented FPG levels in nondiabetic women," the authors write.
Study limitations include cross-sectional design and relatively small sample size.
"Although there are gender differences in the development of diabetes, gender-specific therapies for the prevention of diabetes and its vascular complications have not yet been developed," the authors conclude. "Therapeutic approaches taking into consideration the direct effect of menopause on FPG levels are therefore important for the prevention and treatment of diabetes in postmenopausal women."
The Ministry of Education, Science, Sports, and Culture of Japan supported this study. The authors have disclosed no relevant financial relationships.
Menopause. 2007;14:404-407.
