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CME

Starch Intake May Increase Risk for Benign Prostatic Hyperplasia

  • Authors: News Author: Laurie Barclay, MD
    CME Author:
    Désirée Lie, MD, MSEd
  • CME Released: 6/27/2006
  • THIS ACTIVITY HAS EXPIRED
  • Valid for credit through: 6/27/2007
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Target Audience and Goal Statement

This article is intended for primary care clinicians, urologists, and other specialists who care for patients with BPH.

The goal of this activity is to provide medical news to primary care clinicians and other healthcare professionals in order to enhance patient care.

Upon completion of this activity, participants will be able to:

  • List dietary nutrients that increase or reduce the risk for BPH.
  • Identify nutrients that do not have an impact on the risk for BPH.

 


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Author(s)

  • Laurie Barclay, MD

    Laurie Barclay is a freelance reviewer and writer for Medscape.

    Disclosures

    Disclosure: Laurie Barclay, MD, has disclosed no relevant financial relationships.

Reviewer(s)

  • Gary Vogin, MD

    Senior Medical Editor, Medscape

    Disclosures

    Disclosure: Gary Vogin, MD, has disclosed no relevant financial relationships.

CME Author(s)

  • Désirée Lie, MD, MSEd

    Clinical Professor of Family Medicine; Director, Division of Faculty Development, University of California, Irvine School of Medicine, Irvine, California

    Disclosures

    Disclosure: Désirée Lie, MD, MSEd, has disclosed no relevant financial relationships.


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CME

Starch Intake May Increase Risk for Benign Prostatic Hyperplasia

Authors: News Author: Laurie Barclay, MD CME Author: Désirée Lie, MD, MSEdFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED

CME Released: 6/27/2006

Valid for credit through: 6/27/2007

processing....

June 27, 2006 — Starch may increase the risk for benign prostatic hyperplasia (BPH), whereas polyunsaturated fatty acids may decrease the risk, according to further analysis of an Italian case-control study reported in the June issue of Urology.

"Although BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors, including diet and other lifestyle habits," write Francesca Bravi, MD, from the Istituto di Ricerche Farmacologiche "Mario Negri" in Milan, Italy, and colleagues. "In particular, the potential role of specific macronutrients on BPH has received little attention. However, nutritional factors could be important by influencing hormonal concentrations implicated in prostatic enlargement."

This case-control study included 1369 patients with BPH and 1451 controls, who were admitted to the same hospitals for a wide spectrum of acute, nonneoplastic conditions. Using a validated and reproducible food frequency questionnaire, the investigators determined the subjects' usual diet, and they obtained multivariate odds ratios (ORs) and 95% confidence intervals (CIs) after allowance for energy intake and other potential confounding factors.

Starch intake was related directly to BPH (OR, 1.51; 95% CI, 1.15 - 1.99 for highest quintile compared with lowest one), and polyunsaturated fatty acids intake was related inversely (OR, 0.72; 95% CI, 0.55 - 0.93), as was intake of linoleic acid (OR, 0.73; 95% CI, 0.56 - 0.94) and linolenic acid (OR, 0.71; 95% CI, 0.54 - 0.93).

Study limitations include the absence of a clear case definition of BPH, possible misclassification of controls, and difficulty in assessing long-term dietary patterns.

"The results of this study suggest a role for specific macronutrients in the risk of BPH, including, in particular, an unfavorable effect for starch and a beneficial one for polyunsaturated fatty acids," the authors write. "The issue of BPH and diet, however, remains open to discussion, given the inconsistencies of our results with those of a few previous investigations.

The Italian Association for Cancer Research and the Italian League Against Cancer, Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Pordenone; Servizio di Epidemiologia, Istituto Tumori "Fondazione Pascale," Naples; Servizio Integrato di Epidemiologia e Sistemi Informativi, Istituto "Regina Elena," Rome, Italy; International Agency for Research on Cancer, Lyon, France; and Istituto di Statistica Medica e Biometria,Università degli Studi di Milano, Milan, Italy, supported this study.

Urology. 2006;67:1205-1211