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Rapid-Cycling Bipolar Disorder: Emerging Treatments and Enduring Controversies: Conclusion



Although it has been 30 years since the term rapid cycling was coined, the condition is still something of a mystery. It remains an open question as to whether rapid cycling is a transient or enduring phenomenon, and whether certain pharmacotherapies demonstrate compelling advantages over others. Rapid cycling may represent a negative prognostic factor more than a marker for specific treatment outcomes. Compounds that do not destabilize mood, particularly those with at least a moderate or large effect size for the treatment of depressive symptoms, may represent the most compelling and evidence-based interventions for this condition.

Supported by an independent educational grant from AstraZeneca.