Organ Replacement Technologies: A New Frontier

Cascalho M, Platt JL. Xenotransplantation and other means of organ replacement. Nat Rev Immunol. 2001;1:154-160. Abstract
Sutherland DE. Technologies for organ replacement therapy: Competing or complimentary? Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Watson JT. Toward a totally implantable artificial heart. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Rose EA. Advances in cardiac assist/replacement. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Rose EA, Gelijns AC, Moskowitz AJ, et al, from the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med. 2001;345:1435-1443. Abstract
Griffith BD. Toward an implantable lung. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Haft JW, Griffith BP, Hirschl RB, Bartlett RH. Results of an artificial lung survey to lung transplant program directors. J Heart Lung Transplant. 2002;21:467-473. Abstract
Taylor DA. Cellular cardiomyoplasty with autologous skeletal myoblasts for ischemic heart disease and heart failure. Curr Control Trials Cardiovasc Med. 2001;2:208-210. Abstract
Menasche P. Myoblast transplantation: feasibility, safety and efficacy. Ann Med. 2002;34:314-315. Abstract
Nerem RM. Role of mechanics in vascular tissue engineering. Biorheology. 2003;40:281-287. Abstract
Okarma TB. Human embryonic stem cells: Progress and promise. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Atala AJ. Stem cells, nuclear transfer, and tissue engineering: Challenges and opportunities. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Lanza RP, Chung HY, Yoo JJ, et al. Generation of histocompatible tissues using nuclear transplantation. Nat Biotechnol. 2002;20:689-696. Abstract
Hammerman MR. Transplantation of embryonic kidneys. Clin Sci (Lond). 2002;103:599-612. Abstract
Toledo-Pereyra L. Xenotransplantation: a view to the past and an unrealized promise to the future. Tissue Antigens. 2002;60:551.
Buhler L, Xu Y, Li W, et al. An investigation of the specificity of induced anti-pig antibodies in baboons. Xenotransplantation. 2003;10:88-93. Abstract
Lai L, Prather RS. Progress in producing knockout models for xenotransplantation by nuclear transfer. Ann Med. 2002;34:501-506. Abstract
White DJG. Xenotransplantation and the heart. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Davis RD. Hurdles to xenotransplantation of the lung, one perspective. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.
Briscoe DM, Hertz MI. The future of organ replacement. Panel discussion. Presented at AST Seventh Annual Winter Symposium: Approaches to the Replacement of Organ Function; February 13-16, 2003; Naples, Florida.

processing....

The Implantable Artificial Lung

The implantable artificial lung is an even more "formidable challenge" than the artificial heart, said Bartley P. Griffith, MD,^[6] Director of Heart and Lung Transplantation at the University of Maryland, Baltimore. In the evolution from bubbler to membrane to artificial lung, goals have included efficient gas exchange over a large surface area, durability, biocompatibility, and plasma impermeability. Because the artificial lung is right-heart dependent, it must have low resistance and impedance. The hope is that computerized flow design can optimize blood flow paths and reduce thrombosis, a problem commonly encountered with this technology. On the basis of a survey of lung transplant program directors,^[7] Dr. Griffith reported widespread support for the development and use of an artificial lung as a bridge to lung transplantation. He hopes that transplant centers can facilitate progress by sharing ideas for design of the device with laboratories that are developing artificial lungs.