Lung cancer is the leading cause of cancer death among both men and women; more people die from lung cancer than from colon, breast, and prostate cancers combined. In 2007, more than 200,000 people will develop lung cancer and more than 160,000 people will die from the disease. Incremental improvements are made regularly in the ways in which all treatment modalities (ie, surgery, radiation, and medical therapies) are applied to patients with lung cancer. Practitioners face a continuing challenge in staying on top of new data and recommendations based on recent advances in therapy. These advances include the incorporation of targeted therapies into traditional chemotherapy- and radiation-based regimens for lung cancer.