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Latest Clinical Briefs

About Hematology

Hematology encompasses a wide range of blood and bone marrow disorders and malignancies. For many years, hematologic conditions were categorized and treated based on clinical features, disease course (acute vs chronic), and cellular features (lymphoid vs myeloid). In recent years, a greater understanding of the cellular and molecular biology of hematologic conditions has led to drastic improvements in treatment approaches and, in turn, in patient outcomes. In some cases, such as chronic myeloid leukemia, once-fatal conditions are now often manageable with lifelong therapy. In other cases, such as multiple myeloma, many effective options are now available where once there were few, if any.

Hematologists may find themselves again on the leading edge of treatment as gene therapy for hemophilia undergoes an expedited development path to bring needed therapies to market. Yet, more established therapies including stem cell transplantation, blood transfusions, and chemotherapy remain key components of the management of some hematologic conditions.

With these many new opportunities and challenges, hematology clinicians must stay up-to-date on the latest developments regarding:

• The role of immunophenotyping, molecular profiling, and genetic testing in risk assessment and to help guide treatment
• Strategies for sequencing of therapies and stem cell transplantation
• Approaches to managing relapsed and refractory disease
• The role of combination therapies
• The current status and potential role of new and emerging therapeutic approaches, including cellular therapies and gene therapy
• The management of treatment-related adverse events