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About Gout

Gout is defined as an arthritis associated with the presence of MSU crystals in synovial fluid or tissue. Gout is often classified as primary or secondary and both forms are associated with hyperuricemia. Gout associated with an inborn error in metabolism or decreased renal excretion without other renal disease is referred to as primary gout, whereas gout associated with an acquired disease or the use of a drug is called secondary gout. In both primary and secondary gout, chronic hyperuricemia may be the result of overproduction of uric acid caused by increased purine intake, synthesis, or breakdown, or it may be the result of decreased renal excretion of urate.