Should Age Be Considered with Troponin Testing for Myocardial Injury?

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1. You are a member of the healthcare team seeing a 63-year-old man with a 1-hour history of chest pain with nausea and diaphoresis. You order an electrocardiogram and stat cardiac troponin study. What should you consider regarding the interpretation of cardiac troponin assays?
   The accepted cutoff value for an abnormal troponin is 5 ng/L
   The accepted cutoff value for an abnormal troponin is the 99th percentile of values among healthy adults
   Cardiac troponin levels do not vary by sex
   Cardiac troponin levels generally decline with age
2. The cardiac troponin I level is just below the manufacturer cutoff value for abnormal. What should you consider regarding the implications of this result, based on the results of the current study by McEvoy and colleagues?
   Cardiac troponin I levels among healthy adults were generally lower than manufacturers’ cutoff value
   Cardiac troponin I levels among healthy adults were generally higher than manufacturers’ cutoff value
   Cardiac troponin I levels were not affected by age
   Cardiac troponin I levels were higher among Black adults compared with White adults