CME/CE Test

A 60-year-old heart transplant patient develops severe CMV colitis. His CMV DNAemia (viral load) is 680,000 IU/mL.

According to current CMV guidelines, which of the following is the preferred initial CMV treatment for this patient?

Valganciclovir

Ganciclovir

Foscarnet

Cidofovir

Which laboratory test should be ordered routinely to monitor for side effects of foscarnet?

Viral nucleic acid amplification test

Liver function test

Serum creatinine

Thyroid function test

A viral UL97 kinase mutation at site L595S confers what level of resistance to ganciclovir?

High-level resistance

Low-level resistance

Insignificant resistance

No resistance

A 52-year-old lung transplant patient with renal insufficiency has increasing CMV viral load after 3 weeks of adequately dosed valganciclovir. Genotypic testing reveals a UL97 mutation at site A594V.

Based on the patient’s history and testing results, which of the following is an appropriate therapeutic choice?

High-dose ganciclovir

Foscarnet

Maribavir

Cidofovir

CME/CE Test

Tackling Treatment-Refractory and Drug-Resistant CMV in the Solid Organ Transplant Setting: A Care Team Forum®