Does Long-Term Antidepressant Use Affect Cardiovascular Disease, Mortality Risk?

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1. You are a member of the health care team for a 67-year-old man who has been receiving antidepressant treatment for 3 years. On the basis of the population-based cohort study of UK Biobank participants by Bansal and colleagues, which one of the following statements about the association between use of antidepressants and cardiovascular, coronary heart disease (CHD), cardiovascular disease (CVD) mortality, and all-cause mortality is correct?
   Selective serotonin reuptake inhibitor (SSRI) treatment was linked to increased risk for diabetes and hypertension at 5 years and 10 years
   At 10-year follow-up, SSRI treatment was linked to 34% increased risks for CV and 87% increased risks for CVD mortality
   Associations of increased risk for antidepressant use with adverse outcomes were stronger for SSRIs than for non-SSRIs
   There was some evidence of a dose-response effect for CVD mortality
2. According to the population-based cohort study of UK Biobank participants by Bansal and colleagues, which one of the following statements about clinical implications of the association between use of antidepressants and CV, CHD, CVD mortality and all-cause mortality is correct?
   The study showed good short-term and long-term safety profile of antidepressants
   Most of the substantial antidepressant prescribing increase in the past 2 decades is from new prescriptions
   The study proves that long-term antidepressant use causes adverse cardiovascular outcomes
   Clinicians should review the cardiovascular health of patients receiving antidepressants more proactively