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Is There an Association Between Nonsteroidal Anti-Inflammatory Drug Use and Inflammatory Bowel Disease Exacerbations?

  1. You are a member of the healthcare team seeing a 60-year-old man 2 weeks after a flare of ulcerative colitis. He wants to know why he had an exacerbation. In the previous study by Feagins and colleagues, what was the most significant factor in promoting a higher risk for inflammatory bowel disease (IBD) flare?
    Nonadherence to medication
    Tobacco use
    Antibiotic use
  2. What does the current study by Cohen-Mekelburg and colleagues suggest regarding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and IBD?
    NSAIDs do not appear to increase the risk for IBD flare
    Only ibuprofen can increase the risk for IBD flare
    Only naproxen can increase the risk for IBD flare
    The use of any NSAID can increase the risk for IBD flare