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Can Sugar Substitutes Alter Gut Microbiota?

  1. As part of the healthcare team you are discussing the topic of weight loss with a 30-year-old woman with a body mass index of 33 kg/m2 and a history of prediabetes. The patient consumes 4 soft drinks containing nonnutritive sweeteners (NNS) per day. On the basis of the results of the previous meta-analysis by Lohner and colleagues, what can you tell her?
    NNS are associated with lower body weight compared with sugar
    NNS are associated with lower HbA1c compared with sugar
    NNS are associated with no difference in Hba1c or body weight compared with placebo
    NNS are associated with higher risks for headache and bloating vs comparators
  2. Which of the following NNS were implicated in promoting higher glucose levels on glucose tolerance tests in the current study by Suez and colleagues?
    Saccharin and sucralose
    Aspartame and stevia
    Saccharin, aspartame, and sucralose
    Saccharin, aspartame, stevia, and sucralose