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CME/CE Test

Could Viruses Be the New Artillery Against Inflammatory Bowel Disease?

To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

  1. You are a member of the healthcare team advising a gastroenterology practice about potential new therapeutic approaches to inflammatory bowel disease (IBD). According to the study in vitro, in a mouse model, and in human volunteers by Elinav and colleagues, which one of the following statements about a potential treatment targeting inflammation-causing gut bacteria contributing to IBD by using bacteriophage viruses that infect them is correct?
    Researchers identified a clade of Escherichia coli strains with unique antibiotics resistance strongly linked to IBD exacerbation and severity
    Klebsiella pneumoniae (Kp)-targeting phages were rapidly degraded in an artificial human gut
    Treating colitis-prone mice cells with a 5-phage cocktail effectively suppressed Kp and reduced inflammation, tissue damage, and disease severity. It was also found that in the human phase trial, the orally administered combination phage therapy was well-tolerated.
    In human volunteers, the orally administered combination phage therapy was poorly tolerated
  2. According to the study in vitro, in a mouse model, and in human volunteers by Elinav and colleagues, which one of the following statements about the clinical implications of a potential treatment targeting inflammation-causing gut bacteria contributing to IBD by using bacteriophage viruses that infect them is correct?
    Avoiding antibiotic resistance with the 5-phage cocktail is not feasible
    The 5-phage cocktail suppresses pathogens linked to IBD but also harms beneficial gut bacteria
    The study suggests that IBD can only be successfully managed with antibiotics
    The researchers hope that phage therapy might one day be used with induction therapy in IBD to help quench acute exacerbation, or as maintenance therapy