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Identify And Act: Overcoming Barriers to Managing Homozygous Familial Hypercholesterolemia

  1. What’s the usual LDL threshold for diagnosis of HoFH in adults?
    > 300 mg/dL
    > 400 mg/dL
    > 500 mg/dL
    > 600 mg/dL
  2. Lomitapide can be proposed for patients with HoFH. What was the percentage of reduction of MACE with this agent, according to D’Erasmo et al?
  3. You receive at your office a 30 year-old patient with HoFH with an LDL-C level of 520 mg/dL before any therapy. When would you refer this patient for apheresis?
    As a first-line therapy
    After starting a high-dose statin
    After high-dose statin and ezetimibe
    After maximal dose tolerated therapy