Mechanosensation by Endothelial PIEZO1 Is Required for Leukocyte Diapedesis

Based on the in vitro and mouse model study by Wang and colleagues, which of the following statements about how low flow and leukocyte-induced intercellular adhesion molecule 1 (ICAM-1) clustering interact to mechanically activate endothelial PIEZO1 is correct?

Based on the in vitro and mouse model study by Wang and colleagues, which of the following statements about the role of PIEZO1 activation in signaling processes leading to opening of the endothelial barrier and leukocyte extravasation is correct?

Based on the in vitro and mouse model study by Wang and colleagues, which of the following statements about pathophysiologic and clinical implications of how molecular mechanisms underlying the initial interactions between leukocytes and endothelial cells are linked to opening of the endothelial barrier is correct?