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Is the COVID-19 Vaccine as Effective in Patients on Hemodialysis?

  1. You are a member of the healthcare team for a 62-year-old male patient with a long history of type 2 diabetes, hypertension, and chronic kidney disease. He started hemodialysis 2 years ago and has still not been convinced to get the COVID-19 vaccine. According to the results of the previous study by Andrews and colleagues, what should you consider regarding vaccine efficacy against newer variants of COVID-19?
    Overall vaccine efficacy was similar for the Omicron and Delta variants
    BNT162b2 efficacy against Omicron declined to < 10% at ≥ 25 weeks after a second dose
    A third booster dose of BNT162b2 failed to raise efficacy against Omicron
    There was no evidence of waning of efficacy after the booster of BNT162b2
  2. What can you tell this patient regarding the results of the current study by Ashby and colleagues of patients receiving hemodialysis?
    Only 4% of patients receiving hemodialysis tested positive for SARS-CoV-2
    Nearly 10% of cases of COVID-19 in this cohort required hospital admission
    2 doses of COVID-19 vaccine reduced the risk for hospitalization for COVID-19 by 75%
    BNT162b2 was effective against hospitalization, but AZD1222 was not