Does Orthostatic Hypertension in Young Adults Predict Major Cardiac Events?

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1. You are a member of the healthcare team for a 27-year-old man with stage I hypertension. According to the prospective cohort study by Palatini and colleagues, which of the following statements about the association of orthostatic hyperreactivity with major adverse cardiovascular events (MACE) is correct?
   At baseline, hyperreactors had higher supine systolic blood pressure (SBP), higher total cholesterol, and lower high-density lipoprotein cholesterol (HDL-C)
   Hyperreactors were more likely to be treated for hypertension during follow-up
   24-hour urinary catecholamine measurement showed higher epinephrine/creatinine ratio in normoreactors than in hyperreactors
   Hyperreactivity to standing independently predicted MACE, with nearly twice the risk in hyperreactors vs normoreactors
2. According to the prospective cohort study by Palatini and colleagues, which of the following statements about clinical and public health implications of the association of orthostatic hyperreactivity with MACE is correct?
   In young to middle-aged hypertensive adults, exaggerated SBP response to standing is associated with cholinergic hyperactivity
   Orthostatic BP testing is easily performed in clinical settings and offers prognostic information beyond ambulatory BP monitoring
   The findings can easily be applied to Black women
   Exaggerated SBP response to standing is similar in younger and older hypertensive adults