-
Imaging the Painful Osteoarthritic Knee Joint: What Have We Learned?
MRI may detect osteoarthritis of the knee at earlier stages compared with plain x-rays, and may give insight into the structures affected.
March 02, 2009
-
Neurocognitive Impairment in Children and Adolescents With Systemic Lupus Erythematosus
What is known of the epidemiology and pathophysiology of neurocognitive impairment in systemic lupus erythematosus, and how will this alter diagnostic and therapeutic approaches for these patients?
February 02, 2009
-
A Case of Childhood-onset Ankylosing Spondylitis: Diagnosis and Treatment CME
A 14 year old boy enters the rheumatology clinic with a history of persistent arthritis. What tools can the physician use to diagnose him and what are the best management strategies for treatment?
December 23, 2008
-
Painful Knee Locking Caused by Gouty Tophi Successfully Treated With Allopurinol
A 67-year-old man presented to a rheumatology clinic with a 1-week history of severe pain and swelling in his right knee.
December 01, 2008
-
Vitamin D and Musculoskeletal Health
Hypovitaminosis D, encompassing both vitamin D insufficiency and deficiency, is highly prevalent in the general population and has potentially deleterious musculoskeletal effects.
November 01, 2008
-
Progressive Arm and Leg Stiffness in a Patient With Chronic Renal Impairment
Nephrogenic systemic fibrosis can promote significant disability. While medical treatment for nephrogenic systemic fibrosis is currently limited, prevention is paramount. The current article reviews the diagnosis and prevention of nephrogenic systemic fibrosis.
October 01, 2008
-
Cryopyrinopathies: Update on Pathogenesis and Treatment CME
Cryopyrinopathies are autoinflammatory diseases characterized by recurrent bouts of systemic inflammation that involve several tissues, including joints and skin. New biological agents have provided very encouraging results for patients with these conditions.
September 01, 2008
-
A Case of Adult-onset Satoyoshi Syndrome With Gastric Ulceration and Eosinophilic Enteritis CME
This patient is only the fifth adult in the world reported to have Satoyoshi syndrome, and the first - reported adult case from South Africa.
August 01, 2008
-
Optic Neuritis and Recurrent Myelitis in a Woman With Systemic Lupus Erythematosus
Optic neuritis and myelitis can occur as manifestations of "idiopathic" demyelinating syndromes, such as neuromyelitis optica and multiple sclerosis, as well as of systemic rheumatic syndromes. Knowledge of the distinguishing clinical and radiographic features is crucial for an accurate diagnosis.
July 01, 2008
-
A Case of Undifferentiated Connective Tissue Disease: Is it a Distinct Clinical Entity?
Undifferentiated connective tissue disease (UCTD) presents signs and symptoms suggestive of autoimmune disease but does not meet existing classification criteria for connective tissue disease. The diagnostic criteria, differential diagnoses, and natural history and management of UCTD are reviewed.
June 01, 2008
-
Drug Insight: Choosing a Drug Treatment Strategy for Women With Osteoporosis--An Evidence-Based Clinical Perspective
Identifying women with osteoporosis at high risk of fractures determines which drug therapy is effective at reducing fracture risk. Patient- and drug related determinants of initiating pharmacotherapy for fracture prevention are reviewed.
May 01, 2008
-
Mechanisms of Disease: Antiphospholipid Antibodies -- From Clinical Association to Pathologic Mechanism
Antiphospholipid syndrome (APS) is characterized serologically by the presence of antiphospholipid antibodies. The pathophysiologic mechanisms of and appropriate serologic testing for APS are reviewed.
April 01, 2008
-
Drug Insight: Autoimmune Effects of Medications: What's New?
Many medications have been linked with autoimmune effects. The current review highlights the epidemiology and clinical presentation of autoimmune phenomena associated with medical treatment.
March 01, 2008
-
Tendinopathy -- From Basic Science to Treatment
Tendinopathies refer to conditions of chronic tendon pathology and are difficult to treat. The basic pathophysiology of and the newer management approaches for tendinopathies are reviewed.
February 01, 2008
-
Nonpharmacologic Management of Osteoporosis to Minimize Fracture Risk
January 01, 2008
-
Adipokines As Emerging Mediators of Immune Response and Inflammation
November 14, 2007
-
Pain Measurement in Patients With Low Back Pain
November 01, 2007
-
New Endogenous Anti-Inflammatory and Proresolving Lipid Mediators: Implications for Rheumatic Diseases
October 01, 2007
-
The Assessment of Ankylosing Spondylitis in Clinical Practice
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis, and new treatments offer hope for improved outcomes. The current review describes the best practices for monitoring disease activity in AS.
September 01, 2007
-
Combination Therapy for Rheumatoid Arthritis: Methotrexate and Sulfasalazine Together or With Other DMARDs
Combining DMARDs is preferred initially to treat rheumatoid arthritis, but the most effective regimen is unclear. This review highlights the most commonly used combinations and approaches.
August 01, 2007
