Metastatic Melanoma: Which Treatment, When?CMEExperts discuss relevant choices for therapy of unresectable metastatic disease based on the presence of mutation or a viable immune system.
JNCCN - Journal of the National Comprehensive Cancer Network, March 2012
Smaller Excision Margin Safe in Removal of Thick MelanomasCMEA randomized trial shows that a 2-cm surgical excision margin for cutaneous melanomas thicker than 2 mm results in similar levels of recurrence and death as a 4-cm margin.
Melanoma accounts for the majority of skin cancer-related deaths while remaining one of the rarer forms of skin cancer. Historically, advanced metastatic melanoma has been difficult to treat, but newer targeted and immune-based therapies have recently shown promise in clinical trials. Practitioners are challenged to keep up to date on the latest data regarding the efficacy of these agents, both alone and in combination with the current standard of care, in anticipation of an expanding armamentarium of effective therapies for melanoma.